In response to Engle's 'mouse miles' comment, there are a few settings that may improve your experience a bit.
First off, you can switch the location of the Tool guides with an option in the SpaceCLaim Options > Advanced menu:

You can also push the Status Messages into the top corner of the design window from the SpaceClaim Options > Popular menu:

Together, the two options should give you a more condensed region of UI elements:

Remember also that the panels (Structure, Layer, Options, etc.) can all be docked around in any configuration you like.
Regards,
James